Having checked through the alpaca medical records yesterday I can see that we are very close to giving the last 8 way boosters to some of the mothers before they deliver their 2008 cria.

All alpaca vaccinations are “off label” therefore effectiveness and safety are not guaranteed by the manufacturers.

generally speaking it is best to avoid modified-live vaccines in pregnant animals.
Vaccines may not completely prevent infections but often moderate the disease symptoms experienced by the alpaca.

Individual animal response to a vaccine is variable and can be affected by many factors such as stress, immune status at time of vaccination, and proper storage and administration of the vaccine. A sick animal will not respond as well as a healthy animal. Vaccinate a week or two prior to a stressful event such as shipping or weaning.

Initial vaccinations generally require boosters to generate adequate protection due to the need to prime the immune system and the potential for interference from waning maternal colostral antibodies.

Vaccinations Commonly Used in Alpacas

CD/T

Clostridium perfringens type C, D, and C. tetani
A commonly used vaccine. C. perfringens has been implicated in diarrhea and sudden deaths in crias and occasionally adults. All animals are at risk for tetanus following infection primarily through wounds, castrations and so forth.

Other Clostridial Vaccines

“7 way” and “8 way” clostridial vaccines available. The number refers to the number of diseases the vaccine prevents. Vaccinates against a broad spectrum of clostridial bacteria.
Some contain tetanus.

As always these are just my own protocols developed in conjunction with my local vet and you should do likewise and develop your own protocols that take into account the environmental factors on your farm.